How to Detect Chikungunya? Magnetic Bead Nucleic Acid Extraction Aids

Introduction

The Chikungunya fever outbreak in Guangdong Province is still ongoing. Recent reports indicate the number of cases remains high, although no severe or fatal cases have occurred. In virus detection, magnetic bead nucleic acid extraction, as a mature and reliable technology, provides crucial support for the rapid and accurate diagnosis of cases.

1. Current Outbreak Situation in Guangdong

1.1Case Numbers:

During the week of September 28 to October 4, 2025, Guangdong Province reported 3,181 new local cases of Chikungunya fever. Since mid-September, case numbers have continued to increase, with the province reporting 2,426 new cases during the week of September 14-20 alone.

1.2 Geographical Distribution:

The outbreak is primarily concentrated in Jiangmen City, which reported 2,480 cases during the mentioned period, accounting for the vast majority of provincial cases. Additionally, Foshan, Guangzhou, Zhaoqing, Shenzhen, and other areas have also reported a relatively high number of cases.

1.3 Outbreak Response:

Jiangmen City has activated a Level III public health emergency response. Although the initial rapid upward trend has been preliminarily contained, case numbers continue to fluctuate at high levels.

1.4 Transmission Vector:

Chikungunya fever is primarily transmitted by Aedes albopictus (the Asian tiger mosquito). Current climatic conditions in Guangdong Province, especially in the Pearl River Delta region, remain suitable for mosquito vector breeding, increasing the risk of further outbreak spread.

2. Application of Magnetic Bead Nucleic Acid Extraction

In Chikungunya virus detection, nucleic acid testing is a key method for confirming infection, and magnetic bead nucleic acid extraction is a critical step within this process.

2.1 Technical Principle:

The magnetic bead method is based on Solid Phase Reversible Immobilization (SPRI) technology. It forms an ionic bridge (“DNA-salt ion-carboxyl group”) to adsorb nucleic acids under high-salt conditions and releases them through elution under low-salt conditions, achieving nucleic acid separation and purification.

2.2 Advantages:

• High Efficiency and Speed: Capable of batch processing 96 samples, requiring as little as 20 minutes.
• High Recovery Rate: Magnetic bead recovery rate >98%, yielding high-purity extracted nucleic acids.
• Contamination Control: Fully enclosed design with built-in UV lamp disinfection avoids cross-contamination.
• Wide Applicability: Can be used for nucleic acid purification from various sample types including plasma, serum, whole blood, and viral samples.
• Practical Application: Magnetic bead nucleic acid extraction technology has been widely adopted in numerous CDC labs and medical institutions across the country. It enables automated, high-throughput operation, allowing for nucleic acid extraction from tens to hundreds of samples with a single start command, meeting the demands for large-scale testing during outbreak control.

3. Product Introduction

Shanghai Lingjun Biotechnology Co., Ltd. has developed various models of silica-based magnetic beads widely applicable in the field of pathogen disease diagnosis. Specifically, their magnetic beads with product numbers 160011, 160013, and 160024 can be used for Chikungunya fever nucleic acid extraction.

LnjnBio’s silica-based magnetic beads offer extremely high detection sensitivity, enabling rapid screening during the early stages of infection and securing valuable time for disease control and prevention.

Table 1: Shanghai Leagene Silica-based Magnetic Bead Product Parameters

Product Code	Product Name	Surface Group	Particle Size	Solid Content	Specification
160011	Silica Magnetic Beads	Si-OH	800 nm	50 mg/mL	2mL, 10mL, 50mL, 500mL, 1000mL
160013	Silica Magnetic Beads	Si-OH	1.2 μm	50 mg/mL	2mL, 10mL, 50mL, 500mL, 1000mL
160024	Silica Magnetic Beads	Si-OH	1.4 μm	100 mg/mL	2mL, 10mL, 50mL, 500mL, 1000mL

3.1 Product Advantages:

• High Adsorption Rate: Maximum recovery rate exceeding 95%, with strong adsorption performance for both large and small fragments.
• Strong Magnetic Properties: Magnetic saturation strength greater than 60 emu/g.
• Particularly Suitable For: Viral nucleic acid extraction, serum/plasma free DNA fragment extraction.
• High Purity and Sensitivity: Extracted nucleic acids are of high purity, leading to high detection sensitivity.
• Mature Process and Good Batch Consistency: The manufacturing process is mature, ensuring good stability between production batches.

4. Summary

The Chikungunya fever outbreak remains active in Guangdong Province, particularly in the Jiangmen area, and control efforts are ongoing. In terms of detection, magnetic bead nucleic acid extraction, as a mature and reliable technology, provides a vital guarantee for the rapid and accurate diagnosis of cases, contributing to the timely control of the outbreak’s spread.

Supplier

Shanghai Lingjun Biotechnology Co., Ltd. was established in 2016 which is a professional manufacturer of biomagnetic materials and nucleic acid extraction reagents.

We have rich experience in nucleic acid extraction and purification, protein purification, cell separation, chemiluminescence, and other technical fields.

Our products are widely used in many fields, such as medical testing, genetic testing, university research, genetic breeding, and so on. We not only provide products but also can undertake OEM, ODM, and other needs. If you have a related need, please feel free to contact us .