PEG-Fe3O4 Magnetic Beads: Ushering in a New Era of Precision Medicine and Environmental Management

Introduction

PEG-Fe₃O₄ magnetic beads represent an innovative functional material that seamlessly integrates a superparamagnetic iron oxide (Fe₃O₄) core with a highly biocompatible polyethylene glycol (PEG) shell through advanced nanotechnology. Their unique multifunctional properties make them an ideal platform material for both biomedical and environmental applications.

1.Applications and Mechanisms

1.1 Molecular Diagnostics

• Mechanism: Utilizes superparamagnetism for rapid magnetic separation, while PEG modification reduces nonspecific adsorption and enhances detection specificity.
• Performance: Nucleic acid extraction efficiency >95%, with a detection sensitivity of 200 copies/mL.

1.2 Drug Delivery

• Mechanism: PEG chains provide stealth functionality to prolong blood circulation time; magnetic navigation enables targeted accumulation.
• Performance: Doxorubicin loading capacity of 15%, achieving a 3-5 fold increase in drug concentration at tumor sites.

1.3 MRI Imaging

• Mechanism: The Fe₃O₄ core significantly alters water proton relaxation rates.
• Performance: Transverse relaxivity (r₂) = 180 mM⁻¹s⁻¹, improving signal-to-noise ratio by 40%.

1.4 Heavy Metal Removal

• Mechanism: Functionalized PEG chain terminals provide coordination sites, while magnetism enables rapid recovery.
• Performance: Pb²⁺ adsorption capacity of 185 mg/g, reducing treatment costs by 50%.

1.5 Organic Pollutant Degradation

• Mechanism: Serves as a catalyst support, generating hydroxyl radicals in the presence of H₂O₂.
• Performance: Methylene orange degradation rate >99% within 60 minutes.

2. Technical Advantages

• Precise Control: Particle size and surface functional groups can be customized as required.
• Efficient Separation: Solid-liquid separation achieved within 60 seconds, reducing energy consumption by 70%.
• Safety and Eco-friendliness: Cell viability >95% (at 200 μg/mL, 24h).
• Batch Consistency: Industrial-scale production ensures batch-to-batch variation <5%.

3. Product Introduction

Shanghai Lingjun Biotechnology Co., Ltd. has developed PEG-Fe₃O₄ products suitable for magnetic resonance imaging (MRI) contrast enhancement, drug delivery, targeted therapy, bioseparation, and sensing in the biomedical field. In environmental management, they are applicable for the adsorption and removal of heavy metals or organic pollutants from water. Available in various particle sizes, these products support customized surface functionalization.

Advantages:

• Superparamagnetism: Strong magnetic responsiveness with no remanence, enabling rapid magnetic separation.

• High Biocompatibility: PEG modification effectively reduces nonspecific adsorption and extends in vivo circulation time.
• Excellent Stability: Uniform dispersion in aqueous and physiological buffer systems with strong anti-aggregation properties.
• Surface Functionalizability: Supports conjugation with targeting molecules, fluorescent labels, and other biological ligands.
• Excellent Batch Consistency: Stable manufacturing process ensures high reproducibility.

Table 1: Shanghai Lingjun PEG-Fe₃O₄ Product Parameters

No.	Product Code	Product Name	Particle Size	Solid Content	Specification
1	240061MF	PEG-Fe₃O₄	10 nm	1 mg/mL	2 mL、10 mL、50 mL、500 mL、1000 mL
2	240062MF	PEG-Fe₃O₄	30 nm	1 mg/mL	2 mL、10 mL、50 mL、500 mL、1000 mL
3	240063MF	PEG-Fe₃O₄	50 nm	1 mg/mL	2 mL、10 mL、50 mL、500 mL、1000 mL
4	240064MF	PEG-Fe₃O₄	100 nm	10 mg/mL	2 mL、10 mL、50 mL、500 mL、1000 mL
5	240065MF	PEG-Fe₃O₄	200 nm	10 mg/mL	2 mL、10 mL、50 mL、500 mL、1000 mL
6	240066MF	PEG-Fe₃O₄	300 nm	10 mg/mL	2 mL、10 mL、50 mL、500 mL、1000 mL
7	240067MF	PEG-Fe₃O₄	400 nm	10 mg/mL	2 mL、10 mL、50 mL、500 mL、1000 mL
8	240068MF	PEG-Fe₃O₄	500 nm	10 mg/mL	2 mL、10 mL、50 mL、500 mL、1000 mL

4. Summary

With advancements in surface engineering technologies, PEG-Fe₃O₄ nanomagnetic beads are evolving towards intelligent and multifunctional applications:

Development of integrated multi-modal diagnostic and therapeutic platforms

Construction of real-time environmental pollutant monitoring systems

Achievement of precise drug delivery across biological barriers

5.Conclusion

With their unique design concept and outstanding performance, PEG-Fe₃O₄ nanomagnetic beads are reshaping the technological landscape of biomedical detection and environmental management. We cordially invite partners from all sectors to jointly explore the limitless possibilities of this platform, providing innovative solutions for human health and environmental protection.

Supplier

Shanghai Lingjun Biotechnology Co., Ltd. was established in 2016 which is a professional manufacturer of biomagnetic materials and nucleic acid extraction reagents.

We have rich experience in nucleic acid extraction and purification, protein purification, cell separation, chemiluminescence, and other technical fields.

Our products are widely used in many fields, such as medical testing, genetic testing, university research, genetic breeding, and so on. We not only provide products but also can undertake OEM, ODM, and other needs. If you have a related need, please feel free to contact us .