Revolutioun ASF Testen mat magnetescher Bead Extraktioun Technologie

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一、Magnetic bead-based nucleic acid extraction plays a critical role in the detection of African Swine Fever (ASF), with its high efficiency, Empfindlechkeet, and automation significantly enhancing the accuracy and speed of testing. Below are its specific roles and advantages:

1、Efficient Viral Nucleic Acid Extraction

High-Purity Nucleic Acids: The magnetic bead method specifically binds to nucleic acids (DNA/RNA), effectively isolating the genomic DNA of the African Swine Fever Virus (ASFV) while removing impurities such as proteins and lipids from the sample. This reduces PCR inhibitors and improves the reliability of subsequent detection.

Applicability to Complex Samples: It can process complex matrices such as blood, Stoffer (Mëlz, lymph Wirbelen), and environmental samples, making it particularly suitable for host samples where ASFV often lurks.

2、Enhanced Detection Sensitivity and Specificity

Detection of Low Viral Loads: The strong adsorption capacity of magnetic beads for trace nucleic acids improves the detection rate of low-concentration ASFV, which is especially important for monitoring early or asymptomatic infections.

Reduced False Negatives: Automated operations minimize human errors, and when combined with downstream detection methods such as quantitative PCR (qPCR), specificity can exceed 99%.

3、Rapid, High-Throughput Veraarbechtung

Automated Platforms: The magnetic bead method can be integrated with automated extraction systems, processing dozens to hundreds of samples per run. This is suitable for large-scale screening (z.B., monitoring farms and slaughterhouses), reducing detection time to 1–2 hours.

Emergency Response: During ASF outbreaks, rapid nucleic acid extraction facilitates timely diagnosis and helps control transmission.

4、Biosafety Advantages

Closed-System Operation: The magnetic bead method is often performed in closed kits, reducing aerosol contamination and minimizing operators’ exposure to the virus. This aligns with the biosafety requirements for ASFV, a Biosafety Level 3 pathogen.

5、Compatibility with Multiple Detection Technologies
Extracted nucleic acids can be directly used for:

Real-Time Quantitative PCR (qPCR): The gold standard for ASFV detection, for which the magnetic bead method provides high-quality templates.

Isothermal Amplification Techniques (z.B., LAMP): Suitable for primary-level or field testing.

Sequencing Analysis: Used for viral genotyping and traceability studies.

Magnetic bead-based nucleic acid extraction is a core step in ASF detection. Its high efficiency and automation provide technical support for epidemic monitoring, early diagnosis, and prevention strategies. Combined with molecular techniques such as PCR, it significantly enhances the precision and response speed of ASF detection, making it indispensable for large-scale farming and cross-border quarantine.

二、Advantages of Lingjun Biological Magnetic Beads (Produkt Nr. 160011)

As a core raw material in magnetic bead-based nucleic acid extraction reagents, biological magnetic beads play a decisive role in the nucleic acid extraction process. Lingjun Biological Magnetic Beads (160011) offer the following advantages:

1、Excellent operational performance with strong magnetic properties and short magnetic response time, reducing magnetic separation time.

2、Small particle size with a large surface area, enabling efficient nucleic acid binding and meeting the requirements for nucleic acid extraction from trace biological samples.

3、Suitable for automated extraction, reducing manual operation errors and meeting demands for high throughput and high sensitivity.

4、Excellent stability and batch-to-batch reproducibility.

5、Good storage stability: No aggregation after 1 year of storage at 2–8°C.

三、Applikatioun Fall

The experimental results of Lingjun Biological 160011 magnetic beads combined with Lingjun Biological nucleic acid extraction reagents and a domestic manufacturer’s extraction reagents for the detection of swine fever virus in positive serum samples are as follows:

	Othere extraction reagents	Lingjun extraction reagents
Prouf	Ct值	Ct值
Serum-1	30.66	28.91
	30.81	29.03
Serum-2	21.55	19.41
	21.51	19.37
Serum-3	37.87	33.46
	37.02	33.55
Serum-4	30.25	28.45
	30.24	28.42
Serum-5	39.53	31.60
	37.51	31.82
Serum-6	22.46	20.73
	22.36	20.60
Serum-7	19.14	18.29
	19.31	18.42
Serum-8	33.14	31.24
	32.50	31.38

Resultat Analyse: For both high and low concentration samples, the CT values of Shanghai Lingjun’s extraction reagents were significantly earlier, indicating that the 160011 magnetic beads from Shanghai Lingjun, combined with Lingjun extraction reagents, delivered markedly better extraction efficiency and higher sensitivity.

Fournisseur

Shanghai Lingjun Biotechnology Co., Ltd., Ltd.gouf etabléiert an 2016 deen e professionnelle Hiersteller vu biomagnetesche Materialien an Nukleinsäure Extraktiounsreagenz ass.

Mir hu räich Erfahrung an Nukleinsäure Extraktioun an Offäll, Protein Reinigung, Zell Trennung, Chemilumineszenz, an aner technesch Beräicher.

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